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COMMENTS AND OPINIONS
Inconsistencies and Gaps in Evidence Concerning Vitamins and Risk of Cataract
Samuel Masket, MD;
Flora Lum, MD
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The results of this study1 are limited in their interpretation because of the following: (1) The study did not measure cataract development in a standardized fashion2 according to a standardized grading system. (2) Given that cataract was the main outcome measure, there should have been qualified examinations at entry and exit to identify all cataract cases. (3) The study was observational and thus can strongly suggest an association, but cannot prove a causative effect.2 (4) Other potential confounders may have contributed to the findings. Some potential risk factors that were not identified in the study were race, UV-B exposure, use of systemic corticosteroids, use of inhaled corticosteroids, myopia, and eye trauma.2 (5) The dietary intake and supplement use are based on a single baseline questionnaire. Participants' patterns of dietary intake may have changed during the 10-year follow-up.
Findings from randomized controlled trials yield more . . . [Full Text of this Article]
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