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Sterile Endophthalmitis After Benzyl Alcohol–Filtered Triamcinolone Acetonide Injection
José Lorenzo Carrero, MD, PhD;
Miguel González Barcia, PhD;
Ines Pérez Flores, MD
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Several studies1-2 have described noninfectious endophthalmitis occurring after intravitreous triamcinolone acetonide (TA) injection. According to these articles, this complication occurs in 0.1% to 7% of eyes following treatment. Benzyl alcohol (BA), a bacteriostatic preservative in commercially available TA, has proven toxic to the rabbit eye in concentrations only modestly higher than those found in 0.1 mL of commercially available TA. This has led some investigators to hypothesize that BA may cause sterile endophthalmitis.3 Different techniques, namely, filtration, centrifugation, and sedimentation, were shown to reduce the concentration of BA by 90%.4
Methods
A retrospective, interventional, consecutive case series of intravitreal injection of filtered TA was undertaken. Institutional review board and human studies committee approval were obtained; patients were fully informed and signed an institutional informed consent form. Based on the assumption that filtration has been shown to reduce BA . . . [Full Text of this Article]
Results
Comment
AUTHOR INFORMATION
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