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Juan M. Leyva-Castillo, MSc; Humberto Cavazos-Adame, MD; Augusto Rojas-Martínez, DSc, MD; Martín César Fernández-Espinoza, MD; Rocío Ortiz-López, DSc

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After performing the studies suggested by Dr Tefs and colleagues, we have concluded that their assessment is correct and that the patient recently described by our group¹ does not have the 14–base pair deletion in exon 5 of the PLG gene. A rescreening of exon 5 of the PLG gene with the primers described by Azuma et al² (upstream: 5'-CGG AAT TCA TGT GGT GTC TTG TGA AAG AC-3'; downstream: 5'-CGG GAT CCG GGA CAA CTT TAC AGT AGA TGA ACA C-3') using an annealing temperature of 65°C revealed no additional changes in this exon. We were not able to find additional mutations in the PLG gene sequence that can account for the severe type I plasminogen deficiency in this patient. At the time we submitted the manuscript for review . . . [Full Text of this Article]

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