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Arch Ophthalmol. 2007;125(9):1274.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In 1940 Feldman, Hinshaw, and Moses reported on the action of a sulfonamide preparation—the sodium salt of p, p'-diaminodiphenylsulfone-N, N'-didextrose sulfonate, known as "promin," on experimental tuberculosis in the guinea pig. After this preliminary paper, there appeared a series of reports from these investigators on experimental studies relating to the action of various sulfonamide preparations in tuberculosis. Three sulfones were found which had a definitely deterrent action on the progress of established tuberculosis in the experimental guinea pig. These preparations were "promin," "diasone" (disodium fomaldehyde sulfoxylate diaminodiphenylsulfone) and "promizole" (4, 2'- diaminophenyl-5'-thiazolylsulfone, an isomer of sulfathiazole).

Both "promin" and "promizole" exert a deterrent action on the course of ocular tuberculosis in the immune-allergic rabbit. This deterrent action becomes evident after the third week of treatment. This action of the 2 drugs is about the same.

Histologic evidences of tuberculous disease persist in the majority of the eyes of the treated . . . [Full Text of this Article]