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Predictive Value of Multiple Genetic Testing for Age-Related Macular Degeneration
Dominiek D. G. Despriet, MD;
Caroline C. W. Klaver, MD, PhD;
Cornelia C. van Duijn, PhD;
A. Cecile J. W. Janssens, PhD
Arch Ophthalmol. 2007;125(9):1270-1271.
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The unraveling of the genetic background of age-related macular degeneration (AMD) is occurring at a tremendously fast pace. Researchers have shown that single nucleotide polymorphisms (SNPs) in the CFH, LOC387715, C2/FB, and HTRA1 genes are highly associated with AMD1-10 and have estimated that they explain more than 50% of all cases.2, 4, 7, 10 These genetic discoveries are a major breakthrough for understanding the pathogenesis of the disease, but whether they can be used to improve the prediction of end-stage AMD in individuals at risk is still open to question.11 This requires that testing of multiple SNPs, or genetic profiling, be a better predictor than classic risk factors.
An important step in this direction has been made by Maller et al,12 who investigated the association between 5 variants in . . . [Full Text of this Article]
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ABSTRACT
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