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Risk Factors for Progression

Janey L. Wiggs, MD, PhD

Arch Ophthalmol. 2007;125(9):1264-1265.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

JAMA

Association of CFH Y402H and LOC387715 A69S With Progression of Age-Related Macular Degeneration

Johanna M. Seddon, MD, ScM; Peter J. Francis, MD, PhD; Sarah George, MPH; Dennis W. Schultz, PhD; Bernard Rosner, PhD; Michael L. Klein, MD

Context:  Studies have reported that single-nucleotide polymorphisms in the genes CFH and LOC387715 are associated with age-related macular degeneration (AMD).

Objective:  To assess whether these genetic variants have prognostic importance for progression to advanced AMD and related visual loss.

Design, Setting, and Participants:  Prospective analysis of 1466 white participants in the Age-Related Eye Disease Study (AREDS), a US multicenter clinical trial conducted from 1990 to 2001 with a mean follow-up time of 6.3 years. Age-related macular degeneration status was determined by grading of fundus photographs. Progression (n = 281) was defined as newly diagnosed advanced AMD (geographic atrophy, exudative disease, or AMD causing visual loss) in one or both . . . [Full Text of this Article]