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Michael C. Brodsky, MD; Ammar N. Safar, MD

Arch Ophthalmol. 2007;125(5):710-712.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Tuberous sclerosis is an autosomal-dominant disorder characterized by enhanced proliferation of neural and astrocytic precursors. It is caused by mutations in either TSC1 or TSC2, with loss of hamartin or tuberin function.¹ Affected patients exhibit a specific constellation of neurologic, cutaneous, visceral, and retinal lesions.² The classic triad of epilepsy, adenoma sebaceum, and mental retardation is found in less than one third of cases diagnosed by current criteria.²

Unilateral optic disc elevation in tuberous sclerosis is usually attributable to an astrocytic hamartoma on the surface of the optic disc.^3-4 These phakomas may gradually calcify but generally do not enlarge.^3-4 We document preservation of vision despite massive enlargement of a tumor situated within the optic disc in a child with tuberous sclerosis.

Report of a Case

A 19-month-old girl was found to have swelling of the right optic disc. She had developed seizures at 6 weeks . . . [Full Text of this Article]

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