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Eric K. Chiu, MD; Amy Y. Lin, MD; Robert Folberg, MD; Michael Saidel, MD

Arch Ophthalmol. 2007;125(5):703-705.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Avellino dystrophy is an autosomal dominant corneal stromal disease that shares features of both granular and lattice corneal dystrophies.¹ Molecular genetic techniques have shown that granular, lattice, and Avellino dystrophies share the same genetic locus and map to chromosome 5q. Distinct mutations in the BIGH3 gene cause the various 5q31-linked corneal dystrophies.² These mutations are R555W in granular dystrophy, R124C in lattice type 1, and R124H in Avellino dystrophy.

We report a case of progressive corneal Avellino dystrophy following laser-assisted in situ keratomileusis (LASIK) surgery manifesting clinically as granular dystrophy. This case highlights the importance of combining molecular testing with clinical and histopathological phenotypes.

Report of a Case

The patient, a 53-year-old white man, complained of a bilateral decrease in vision over 7 years. He described the visual loss as affecting his right eye more than his left eye. There . . . [Full Text of this Article]

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