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Visualization of Lipofuscin Accumulation in Stargardt Macular Dystrophy by High-Resolution Fourier-Domain Optical Coherence Tomography
Christina Gerth, MD;
Robert J. Zawadzki, PhD;
Stacey S. Choi, PhD;
John L. Keltner, MD;
Susanna S. Park, MD, PhD;
John S. Werner, PhD
Arch Ophthalmol. 2007;125(4):575.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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A 15-year-old patient was diagnosed with Stargardt macular dystrophy based on maculopathy (Figure 1) and abnormal multifocal electroretinographic responses. Retinal images were obtained with high-speed (up to 18 000 A-scans/s; 18 frames/s; 1000 lines/frame), high-resolution (axial ~ 4.5 µm; lateral 10-15 µm) Fourier-domain optical coherence tomography (FDOCT) (constructed at University of California, Davis).1-2 The FDOCT revealed well-demarcated oval to round "bumps" within the retinal pigment epithelial layer extending from subfoveal to 5° extrafoveal (Figure 2A). The outer nuclear layer was not detectable in this area when compared with an age-matched control (Figure 2B).
Figure appears in full text version.
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Figure 1. Fundus photograph and fluorescein angiography (FA) of the left eye. A, Perimacular yellowish flecks and blunting of the foveal reflex are seen (visual acuity: 20/150 with extrafoveal fixation). . . . [Full Text of this Article]
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