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Improvement of Noninfectious Uveitis With Fumaric Acid Esters: Results of a Pilot Study
Carsten Heinz, MD;
Arnd Heiligenhaus, MD
Arch Ophthalmol. 2007;125(4):569-571.
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Noninfectious endogenous uveitis often improves under corticosteroid therapy, second-line immunosuppressive drugs, or "biologicals." Although they are very helpful, their use might be limited by their adverse effects.
The aim of this pilot study was to investigate the effect of fumaric acid esters (FAEs), which are used for the treatment of psoriasis on endogenous noninfectious intermediate or posterior uveitis. Besides the clinical response, treatment-related modulation of the peripheral blood mononuclear cells was investigated.
Methods
Inclusion criteria were noninfectious endogenous uveitis and vision-threatening complications without inflammatory quiescence under current systemic steroid medication or a maintenance dosage that would otherwise be an indication for a second-line immunosuppressive medication. Visual acuity was above 20/200 in the better eye. The study design complied with the Declaration of Helsinki ethical standards. The local ethics committees approved the study. Informed consent was obtained from the patients. Overall, 4 patients with bilateral uveitis . . . [Full Text of this Article]
Results
Comment
AUTHOR INFORMATION
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