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Nastaran Rafiei, MD; Homayoun Tabandeh, MD; Marc Hirschbein, MD

Arch Ophthalmol. 2007;125(3):421.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Skin necrosis is a rare complication of warfarin therapy that occurs between the third and 10th days of treatment. The pathogenesis of warfarin-induced skin necrosis is attributable to the emergence of a transient hypercoagulable state. The condition most commonly involves skin areas with abundant subcutaneous adipose tissue such as the breasts, buttocks, abdomen, thighs, and the extremities. We report the case of an 83-year-old woman who developed bilateral medial canthal skin necrosis following initiation of warfarin therapy.

Report of a Case

An 83-year-old white woman with a history of aortic valve disease, hypertension, and anemia was admitted for elective aortic valve replacement. Her ocular history was notable for glaucoma and macular degeneration in both eyes. Following surgery, she developed atrial fibrillation and started taking Lovenox (Sanofi-Aventis, Bridgewater, NJ) (30 mg every 12 hours), subsequently replaced by warfarin (4 mg every day), maintaining the international normalized . . . [Full Text of this Article]

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