JAMA
Statin Use and Incident Nuclear Cataract
Barbara E. K. Klein, MD, MPH; Ronald Klein, MD, MPH; Kristine E. Lee, MS; Lisa M. Grady, BS
Context: Statins are widely prescribed for their lipid-lowering effects but also have putative antioxidant properties. Oxidative stress is believed to play a role in the development of nuclear cataract, but little is known regarding the relationship of statin use and cataract incidence.
Objective: To evaluate the relationship of use of statins and incident cataract in adults in a midwestern community in the United States.
Design, Setting, and Participants: The Beaver Dam Eye Study, an observational, longitudinal, population-based study of age-related eye disease in Beaver Dam, Wis. There were 1299 persons who were seen at the third examination in 1998-2000, had gradable photographs in both eyes, and were deemed to be at risk of developing nuclear cataract within 5 years.
Main Outcome Measure: Five-year incidence of . . . [Full Text of this Article]