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The GLC1H Glaucoma Locus May Reflect Glaucoma With Elevated Intraocular Pressure—Reply
Mansoor Sarfarazi, PhD;
Anne Child, MD, FRCP;
Ronald Pitts Crick, FRCS
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In reply
Adult-onset primary open-angle glaucoma (POAG) is a heterogeneous group of eye conditions that results from mutations in many different genes. One primary risk factor for POAG is elevated IOP. Many different genetic locations have been identified for POAG and IOP independently; however, most of these do not map within close proximity of each other. Recently, we mapped a new POAG locus (GLC1H) on chromosome 2p15-p16.1 The Beaver Dam Eye Study2 also reported evidence for an IOP locus near D2S1777 only by analyses of sibling pairs (P = .007) and not nuclear families (P = .10). Duggal and colleagues have now hypothesized that these 2 genetic loci may code for the same product that controls elevated IOP in the families with POAG linked to the GLC1H locus. While this may be a valid assumption, it is . . . [Full Text of this Article]
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RELATED LETTER
The GLC1H Glaucoma Locus May Reflect Glaucoma With Elevated Intraocular Pressure
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Arch Ophthalmol. 2007;125(12):1716-1717.
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A New Locus (GLC1H) for Adult-Onset Primary Open-angle Glaucoma Maps to the 2p15-p16 Region
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