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The GLC1H Glaucoma Locus May Reflect Glaucoma With Elevated Intraocular Pressure
Priya Duggal, PhD, MPH;
Alison P. Klein, PhD;
Kristine E. Lee, MS;
Ronald Klein, MD, MPH;
Barbara E. K. Klein, MD, MPH;
Joan E. Bailey-Wilson, PhD
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We read with interest the recent article by Suriyapperuma et al1 on the identification of a new locus (GLC1H) for adult-onset primary open-angle glaucoma to chromosome 2p15-p16. They performed genetic linkage analysis on 49 members of a single family, with 10 affected individuals with glaucoma. The patients with glaucoma each had moderate to high intraocular pressure (IOP) in at least 1 eye (IOP > 22 mm Hg [range, 22-40 mm Hg]) prior to treatment. Suriyapperuma and colleagues identified a maximum logarithm of the odds (LOD) score at marker D2S370 (LOD = 2.97). Additional families refined this locus and the LOD score increased to 9.30 at D2S2320. We are intrigued because in our recent genetic linkage analysis of IOP in the Beaver Dam Eye Study,2 we . . . [Full Text of this Article]
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The GLC1H Glaucoma Locus May Reflect Glaucoma With Elevated Intraocular Pressure—Reply
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Arch Ophthalmol. 2007;125(12):1717.
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A New Locus (GLC1H) for Adult-Onset Primary Open-angle Glaucoma Maps to the 2p15-p16 Region
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