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Risk Factors for Contact Lens–Related Fusarium Keratitis—Reply
Seang-Mei Saw, PhD, MPH;
Peng-Lim Ooi, MBBS, MPH, MSc;
Donald T. H. Tan, FRCS(Glasg);
Wei-Boon Khor, MBBS;
Chee-Weng Fong, MSc, MSocSc;
Jayne Lim, BSc(Hons);
Howard Y. Cajucom-Uy, MD;
Derrick Heng, MBBS, MRCP, MPhil;
Suok-Kai Chew, MBBS, MSc, DLSHTM;
Tin Aung, PhD, FRCS(Edin);
Ai-Ling Tan, FCRPA;
Cheng-Leng Chan, BSc(Pharm)(Hons);
Steven Ting, MSc(Stats);
Paul A. Tambyah, MBBS;
Tien-Yin Wong, PhD, FRCS(Edin)
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In reply
Our study showed significant increased risks (odds ratio, 21.5; 95% confidence interval, 4.0-115.5; P < .001) of contact lens–related Fusarium keratitis with the use of ReNu MultiPlus. We have not, however, inferred a causal relationship. The criteria for a cause and effect relationship include biological plausibility, a strong association, temporality of the association, a dose-response trend, lowering of risks with the removal of exposure, and consistency of findings across different studies.1 Our findings were not consistently replicated in Hong Kong or the United States.2-4
In Singapore, both ReNu MultiPlus and . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTER
Risk Factors for Contact Lens–Related Fusarium Keratitis
Brian Levy
Arch Ophthalmol. 2007;125(12):1715-1716.
EXTRACT
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RELATED ARTICLE
An Outbreak of Fusarium Keratitis Associated With Contact Lens Wear in Singapore
Wei-Boon Khor, Tin Aung, Seang-Mei Saw, Tien-Yin Wong, Paul A. Tambyah, Ai-Ling Tan, Roger Beuerman, Li Lim, Wing-Kwong Chan, Wee-Jin Heng, Jimmy Lim, Raymond S. K. Loh, Sao-Bing Lee, and Donald T. H. Tan
JAMA. 2006;295(24):2867-2873.
ABSTRACT
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