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Brice Dille, MD

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In the April 2007 issue of the Archives, Soheilian et al¹ discussed prophylaxis of acute posttraumatic bacterial endophthalmitis. Although the study seems well designed, I was very surprised that the prophylactic treatment included the intravitreal injection of gentamicin sulfate. Conway and Campochiaro² (in this same journal) discussed back in 1986 how gentamicin can cause macular infarction in the setting of trauma. Again in the Archives, this time in 1989, Conway et al³ showed in primate retinas that gentamicin is definitely toxic, implying that it should never be used intraocularly. Although Soheilian and colleagues discussed studies in rabbits where gentamicin is not toxic when used in an infusion fluid, as recently as December 2005 Hancock et al⁴ reiterated the significant toxicity of gentamicin in both rabbit and rat retinas. With a quick literature search, at least 9 journal articles can be found discussing the significant retinal . . . [Full Text of this Article]

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RELATED LETTER

Toxicity of Intraocular Gentamicin—Reply
Masoud Soheilian, Nasrin Rafati, Shahin Yazdani, and for the Traumatic Endophthalmitis Trial (TET) Research Group
Arch Ophthalmol. 2007;125(10):1442-1443.
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RELATED ARTICLE

Prophylaxis of Acute Posttraumatic Bacterial Endophthalmitis: A Multicenter, Randomized Clinical Trial of Intraocular Antibiotic Injection, Report 2
Masoud Soheilian, Nasrin Rafati, Mohammad-Reza Mohebbi, Shahin Yazdani, Houshang Faghihi Habibabadi, Mostafa Feghhi, Hossein A. Shahriary, Jamil Eslamipour, Niloofar Piri, Gholam A. Peyman, and for the Traumatic Endophthalmitis Trial (TET) Research Group
Arch Ophthalmol. 2007;125(4):460-465.
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