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Ophthalmic GeneticsAt the Dawn of Discovery
Leslie Hyman, PhD;
Barbara Klein, MD, MPH;
Barbara Nemesure, PhD;
Janey Wiggs, MD, PhD
Arch Ophthalmol. 2007;125(1):9-10.
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Now this is not the end. It is not even the beginning of the end. But it is, perhaps, the end of the beginning.—Winston Churchill, 1942
Ophthalmic genetics is undergoing a major transformation. The role of heredity in ocular disease has been explored for more than 100 years, with the early focus on conditions that could be identified specifically as straightforward mendelian inherited disorders. In these disorders replication of the trait is easily observed, and clear-cut probabilities of transmission can be readily calculated. The discovery of DNA and advances in DNA-related technologies have led to significant advances in the genetics of all diseases (and traits), including those affecting the visual system. Progress in the field has accelerated, aided by the completion of the Human Genome Project in 2003 and the International HapMap Project in 2005. . . . [Full Text of this Article]
AUTHOR INFORMATION
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