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Adverse Effects of Cyclooxygenase-2 Inhibitors on Ocular Vision
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Fraunfelder et al1 summarized possible ocular adverse effects associated with cyclooxygenase (COX)–2 inhibitors, and they described previous articles2-3 reporting transient visual disturbance. We would like to comment on this review and add additional adverse events not mentioned in the article by Fraunfelder and colleagues.
Nonsteroidal anti-inflammatory drugs are frequently used to treat acute or chronic inflammatory disease. Conventional nonsteroidal anti-inflammatory drugs inhibit 2 distinct isoforms of COX-1 and COX-2. Whereas COX-1 resembles several structural elements that are important for mucosal integrity, COX-2 produces prostaglandins and increases the inflammatory reaction. Novel selective COX-2 inhibitors were designed to provide similar anti-inflammatory efficiency with fewer adverse effects. However, randomized studies found a greater incidence of cardiovascular thrombotic events.
First, we previously described patients who developed central or branch retinal vein occlusion soon after initiation or after doubling the dosage of COX-2 inhibitors.4-5 We postulated that COX-2 inhibitors may have triggered thrombotic events in . . . [Full Text of this Article]
AUTHOR INFORMATION
Carsten H. Meyer, MD;
Stefan Mennel, MD;
Jörg C. Schmidt, MD;
Peter Kroll, MD
RELATED LETTER
Adverse Effects of Cyclooxygenase-2 Inhibitors on Ocular Vision—Reply
Frederick W. Fraunfelder
Arch Ophthalmol. 2006;124(9):1368.
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RELATED ARTICLE
Ocular Adverse Effects Associated With Cyclooxygenase-2 Inhibitors
Frederick W. Fraunfelder, Jonathan Solomon, and Thomas J. Mehelas
Arch Ophthalmol. 2006;124(2):277-279.
EXTRACT
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