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Paul J. Botelho, MD; Nathan G. Congdon, MD, MPH; James T. Handa, MD; Esen Karamursel Akpek, MD

Arch Ophthalmol. 2006;124:1356-1357.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Infants with significant corneal opacities are at risk for development of profound deprivation amblyopia without surgical intervention. Early corneal transplantation is recommended. However, penetrating keratoplasty (PK) in young children is considered a high-risk procedure. Additionally, a poorer prognosis has been described in children with congenital corneal opacities when compared with acquired corneal opacities.^1-2 Allograft rejection is the cause in the great majority of pediatric graft failures.

Implantation of a keratoprosthesis, or a synthetic cornea, is considered for patients who are at high risk for donor corneal transplantations. Although significant early and late postoperative complications can occur, favorable results have been achieved in patients with a relatively healthy ocular surface, such as in cases with multiple immunologic graft failures.³

To date, keratoprosthesis implantation has been exclusively performed in adult patients. The success in children . . . [Full Text of this Article]

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