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Localized, Central Optic Snowflake Degeneration of a Polymethyl Methacrylate Intraocular Lens: Clinical Report With Pathological Correlation
Nathan Dahle, MD;
Liliana Werner, MD, PhD;
Luther Fry, MD;
Nick Mamalis, MD
Arch Ophthalmol. 2006;124:1350-1353.
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Snowflake degeneration is a slowly progressive opacification of polymethyl methacrylate (PMMA) intraocular lenses (IOLs), occurring sometimes 10 years or more after implantation.1-2 It has been hypothesized that this degeneration is a result of long-term UV exposure. The dry snowflake lesions, which represent a breakdown in the PMMA material, should be differentiated from glistenings, which are fluid-filled intraoptical vacuoles.3-4 We report a case where the snowflake lesions were lim ited to the central 2 mm of the optic on examination of the explanted PMMA lens in the dry state. However, clinically and on hydration of the explanted lens, the area of central optic opacification extended to a 4-mm diameter. An unusual collection of water may have occurred because of the numerous cracks and fissures present within this area.
Report of a Case
A 90-year-old man with a history of diabetes mellitus since . . . [Full Text of this Article]
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