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Carol L. Shields, MD; Hong Sun, MD; Maria E. Manquez, MD; Ann Leahey, MD; Anna T. Meadows, MD; Jerry A. Shields, MD

Arch Ophthalmol. 2006;124:1196-1197.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Iris neovascularization (NVI) in eyes with newly diagnosed retinoblastoma is a hallmark of advanced tumor.¹ These eyes often display secondary glaucoma and additional partial or complete retinal detachment. From a clinical perspective, NVI with secondary glaucoma is noted in approximately 12% of eyes with retinoblastoma, and from a pathology perspective, NVI has been found in 44% of eyes following enucleation.^2-4 Iris neovascularization is considered a poor prognosis for globe salvage and vision; thus, enucleation is typically advised.

Eyes with advanced retinoblastoma can show a favorable response to chemoreduction.⁵ We have had experience with 2 patients with bilateral advanced retinoblastoma who each showed evidence of NVI in one eye. Because both eyes were possibly destined for enucleation, chemoreduction was provided. Fortunately, the NVI resolved by 1-month follow-up and neovascular . . . [Full Text of this Article]

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