This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Retinal/ Chorioretinal Disorders  • Alert me on articles by topic

Niall Patton, MRCOphth; Tze Lai, MBBS(Hons); Peter Robbins, FRCPA; David Holthouse, MBBS(Hons); Chris Barry, MMedSci; Ian Constable, FRACO, FRACS

Arch Ophthalmol. 2006;124:1193-1195.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Langerhans cell histiocytosis (LCH) is a rare disease of the mesenchymal dendritic cell system caused by a clonal proliferation of dendritic cells with Langerhans cell characteristics that may affect any organ, often with multisystem involvement¹ and predominantly in children.² Langerhans cell histiocytosis exhibits the characteristics of chronic inflammation, with typical granulomas consisting of CD1a-positive Langerhans cells, macrophages, T lymphocytes, and multinucleated giant cells and eosinophils.³ The most common central nervous system manifestation in LCH is involvement of the hypothalamic-pituitary region. Cerebral parenchymal involvement outside of the hypothalamic-pituitary axis by LCH is rare and may occur in the setting of multifocal systemic disease. Solitary unifocal LCH involving cerebral parenchyma is exceptionally rare.^4-5 Ocular involvement in LCH is well recognized, but it normally manifests as eyelid or orbital infiltration^6-8 and may involve multiple . . . [Full Text of this Article]

Report of a Case


Comment

AUTHOR INFORMATION