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Possible Shared Pathogenesis of the Retinoinvasive Phenotype of Malignant Medulloepithelioma and Malignant Melanoma of the Ciliary Body
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In the August 2005 issue of the ARCHIVES, Drs Font and Rishi described a 43-year-old man with an intriguing medulloepithelioma of the ciliary body.1 The retina was thickened and its surface was studded with multiple nodules that, by light microscopy, corresponded to intraretinal invasion and diffuse seeding along the surface of the retina and vitreous. In addition, seedlings were found along the anterior segment structures.
Font and Rishi believed that the unusual pattern of spread was unlikely to be related to prior cyclectomy.1 They refrained from speculations about the pathogenesis of the phenotype.
We were struck by similarities between their case and 4 unusual melanomas of the ciliary body that were described previously.2-4 Their pertinent features were a ring melanoma of the ciliary body, uninvolved choroid, retrocorneal and posterior chamber growth, secondary glaucoma, invasion of the anterior sclera, vitreous seeds, widespread invasion of nonadjacent retina (preferably adjacent to . . . [Full Text of this Article]
AUTHOR INFORMATION
Tero Kivelä, MD, FEBO;
Paula Summanen, MD, FEBO
RELATED LETTER
Possible Shared Pathogenesis of the Retinoinvasive Phenotype of Malignant Medulloepithelioma and Malignant Melanoma of the Ciliary Body—Reply
Ramon L. Font and Kirtee Rishi
Arch Ophthalmol. 2006;124(7):1067.
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RELATED ARTICLE
Diffuse Retinal Involvement in Malignant Nonteratoid Medulloepithelioma of Ciliary Body in an Adult
Ramon L. Font and Kirtee Rishi
Arch Ophthalmol. 2005;123(8):1136-1138.
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