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Asymmetrical Ocular Involvement and Persistent Fetal Vasculature in an Adult With Osteoporosis-Pseudoglioma Syndrome
Timothy Y. Y. Lai, MMedSc, MRCS;
Victoria W. Y. Wong, MMedSc, MRCS;
Dennis S. C. Lam, MD, FRCS, FRCOphth
Arch Ophthalmol. 2006;124:422-423.
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A 22-year-old woman who was diagnosed as having osteoporosis-pseudoglioma (OPPG) syndrome confirmed by genetic testing was referred for ophthalmic assessment. The patient had no history of pathological fracture with normal x-ray films of the wrist and ankle. However, she was found to have osteoporosis on bone densitometry that showed a low bone mineral density at the spine with a T score of –2.8. She also has other clinical features of OPPG syndrome including short stature and a history of amblyopia in the right eye. Her best-corrected visual acuity was 2/60 OD and 20/30 OS, and the manifest refraction was –2.00 diopter sphere/–2.00 diopter cylinder x 85 OD and –2.50 diopter sphere/–3.00 diopter cylinder x 22 OS. Examination of the anterior segment showed right-sided microphthalmia with a Y-shaped anterior sutural cataract. Fundus examination . . . [Full Text of this Article]COMMENT
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