 |
|
Evaluation of the Penetration of Fluoroquinolones in Human Conjunctival Tissue
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
Wagner et al1 described the penetration of topical fluoroquinolones into conjunctival tissue and concluded that efficacy relies primarily on structure, mechanism of action, and penetration into the intended site of action, thereby providing "greater efficacy and more expedient elimination of bacteria."1 They concluded that their study gives a new dual-biopsy technique that may become "a universally approved, standardized means of evaluating topical ocular antibiotics."1 However, measuring antibiotic concentrations in the conjunctiva is only 1 of many ways to measure the efficacy of topical antibiotics.
Although conjunctival and corneal tissue antibiotic concentrations are important factors in determining antibiotic efficacy, one must also take into consideration minimum inhibitory concentrations, tolerability, and toxicity.
Ciprofloxacin achieved high conjunctival concentrations. However, probably related to its low pH (pH 4.5), ciprofloxacin precipitated on the cornea in 15.2% of patients with bacterial keratitis and slowed reepithelialization by 55%.2 Ciprofloxacin's minimum inhibitory concentrations are not as low as . . . [Full Text of this Article]
AUTHOR INFORMATION
Richard G. Fiscella, RPh, MPH;
Michael K. Jensen, RPh, MBA
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED LETTERS
Evaluation of Moxifloxacin, Ciprofloxacin, Gatifloxacin, Ofloxacin, and Levofloxacin Concentrations in Human Conjunctival Tissue
Rudolph S. Wagner, Mark B. Abelson, Aron Shapiro, and Gail Torkildsen
Arch Ophthalmol. 2005;123(9):1282-1283.
EXTRACT
| FULL TEXT
Evaluation of the Penetration of Fluoroquinolones in Human Conjunctival Tissue—Reply
Rudolph S. Wagner
Arch Ophthalmol. 2006;124(12):1797.
EXTRACT
| FULL TEXT
|
