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Glial and Neural Response in Short-term Human Retinal Detachment
Louisa Wickham, MBBS, MRCOphth;
Charanjit S. Sethi, FRCOphth;
Geoffrey P. Lewis, PhD;
Steven K. Fisher, PhD;
David C. McLeod, MD, PhD;
David G. Charteris, MD
Arch Ophthalmol. 2006;124:1779-1782.
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Histopathological changes following acute retinal detachment have been well documented in animal models.1-3 To date, however, the changes that follow an acute human retinal detachment are not well characterized owing to the difficulty in obtaining retinal specimens. When retinal detachment is complicated by proliferative vitreoretinopathy, samples obtained from patients undergoing retinectomy provide an insight into the pathologic abnormalities of more chronic stages of retinal detachment. These changes include glial cell intermediate filament up-regulation, glial extensions into epiretinal and subretinal membranes, photoreceptor outer and inner segment disorganization, opsin redistribution, photoreceptor axon retraction and neurite extension, and second- and third-order neurone remodeling.4 In this histopathological case report, we extend our previous studies to the analysis of a patient with a short-term retinal detachment.
Report of a Case
A 74-year-old woman was . . . [Full Text of this Article]
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