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Effects of Intravitreous Injection of Preserved and Nonpreserved Triamcinolone in Rabbit Retina
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We read with interest the article by Dierks et al1 comparing the short-term effects of intravitreal injection of Kenalog-40 (Bristol-Myers Squibb, Princeton, NJ) with intravitreal injection of the vehicle and of triamcinolone acetonide in rabbit eyes. A 10% to 25% increase in a- and b-wave electroretinographic amplitudes of eyes with intravitreal injection of Kenalog-40 or triamcinolone compared with noninjected eyes was reported, although the probability of this being a chance finding (P value) was not stated.
Furthermore, the ratio of a- and b-wave amplitudes in the injected eyes to control eyes was compared across groups; there were no statistical differences except for an increase in the dark-adapted b-wave amplitude ratio only between the Kenalog-40 and vehicle groups at only 1 of 7 stimulating intensities (there was no statistical difference comparing intravitreal injection of the vehicle with intravitreal injection of triamcinolone). Details concerning the Bonferroni correction, which adjusts for multiple . . . [Full Text of this Article] AUTHOR INFORMATION
Petros E. Carvounis, BMBCh;
Muhammad Abd El Barr, MS;
Thomas A. Albini, MD;
Eric R. Holz, MD
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RELATED LETTER
Effects of Intravitreous Injection of Preserved and Nonpreserved Triamcinolone in Rabbit RetinaReply
Dustin Dierks, Bo Lei, Keqing Zhang, and Dean P. Hainsworth
Arch Ophthalmol. 2006;124(11):1666-1668.
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RELATED ARTICLE
Electroretinographic Effects of an Intravitreal Injection of Triamcinolone in Rabbit Retina
Dustin Dierks, Bo Lei, Keqing Zhang, and Dean P. Hainsworth
Arch Ophthalmol. 2005;123(11):1563-1569.
ABSTRACT
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