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Optic Nerve Structure in Healthy Subjects—Reply
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In reply
In a recent study,1 we investigated structural and functional differences between the eyes of healthy blacks and whites, as blacks tend to be disproportionately affected by primary open-angle glaucoma.2 We found that blacks had a significantly thicker RNFL in the superior and inferior quadrants and larger optic discs than whites. Our interpretation of these findings is that large discs may contain more nerve fibers than small discs. This is consistent with histological evidence showing that healthy blacks have larger optic discs than whites3 and that in monkeys, the number of nerve fibers is positively correlated with the size of the optic nerve.4 Savini and colleagues, however, have suggested that our results could instead be explained by an artifact associated with the fixed diameter used for the circular scans of the OCT. These scans are centered on the optic disc and performed at a fixed diameter of 3.4 mm. . . . [Full Text of this Article]
AUTHOR INFORMATION
Lyne Racette, PhD;
Catherine Boden, PhD;
Shannon L. Kleinhandler, BSc;
Christopher A. Girkin, MD;
Jeffrey M. Liebmann, MD;
Linda M. Zangwill, PhD;
Felipe A. Medeiros, MD;
Christopher Bowd, PhD;
Robert N. Weinreb, MD;
M. Roy Wilson, MD;
Pamela A. Sample, PhD
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Optic Nerve Structure in Healthy Subjects
Giacomo Savini, Maurizio Zannini, Valerio Carelli, Alfredo A. Sadun, Fred N. Ross-Cisneros, and Piero Barboni
Arch Ophthalmol. 2006;124(10):1507.
EXTRACT
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Differences in Visual Function and Optic Nerve Structure Between Healthy Eyes of Blacks and Whites
Lyne Racette, Catherine Boden, Shannon L. Kleinhandler, Christopher A. Girkin, Jeffrey M. Liebmann, Linda M. Zangwill, Felipe A. Medeiros, Christopher Bowd, Robert N. Weinreb, M. Roy Wilson, and Pamela A. Sample
Arch Ophthalmol. 2005;123(11):1547-1553.
ABSTRACT
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