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Arch Ophthalmol. 2006;124:130-132.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The historical association of defects in copper transport, increased serum copper levels, decreased ceruloplasmin levels, and copper deposition in the peripheral limbal cornea is well described in the clinical entity of Wilson (hepatolenticular) disease. However, a rarer pattern of copper deposition in the central cornea may occur with hypercupremia associated with monoclonal gammopathies. Copper deposition in the central Descemet membrane along with anterior and posterior lens capsules has been reported in individuals with multiple myeloma,^1-3 benign monoclonal gammopathy,⁴ and IgG monoclonal gammopathy associated with pulmonary carcinoma.⁵ We report a 30-year catamnesis, a follow-up medical history of a patient who was first described in the ARCHIVES in 1975. She initially complained of blurred vision and a subjective change in her "iris color." She was noted to have copper deposition in the Descemet membrane of the central cornea and in the anterior and posterior lens capsules and was subsequently diagnosed with . . . [Full Text of this Article]

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AUTHOR INFORMATION
Seema Garg, MD, PhD; Lee M. Jampol, MD; Richard A. Lewis, MD; John A. Penner, MD

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