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Akbar Shakoor, MD; Normal P. Blair, MD; Mahnaz Shahidi, PhD

Arch Ophthalmol. 2005;123:1278-1279.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The retinal depression sign was first described in sickle cell retinopathy in 1978 by Goldbaum.¹ It represents an area of focal retinal infarction that may occur not only in the retinopathy of sickling hemoglobinopathies, but also in other microvascular disorders such as diabetic² and hypertensive³ retinopathies.

A 10-year-old African American boy with homozygous sickle cell anemia came to the University of Illinois Medical Center Vitreoretinal Service, Chicago, for a routine ophthalmologic evaluation. Significant findings on indirect ophthalmoscopy included tortuous retinal veins and possibly the retinal depression sign superotemporal to the fovea in the left eye, which were more evident on fundus photography (Figure 1). Retinal thickness analysis (RTA; Talia Technology Ltd, Tel Aviv, Israel) and optical coherence tomography (StratusOCT; Carl Zeiss Meditec Inc, Dublin, Calif) of the left eye were performed. The retinal depression sign was well defined . . . [Full Text of this Article]

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