Rosiglitazone is in the thiazolidinedione class of insulin-sensitizing agents used for the treatment of type 2 diabetes mellitus.
Thiazolidinediones have been reported to cause or exacerbate ventricular failure, pulmonary edema, and peripheral edema, especially in patients with left ventricular dysfunction or chronic renal insufficiency.1-2 This case report describes vision loss in a diabetic patient due to rosiglitazone-induced macular edema, which reversed on dosage reduction.
Report of a Case
A 55-year-old man noted an insidious decrease in vision in each eye during a 2-week period. He had a history of diabetes mellitus (diagnosed in 1987) complicated by proliferative diabetic retinopathy, neuropathy, and recently discovered nephropathy. Hypertension, hyperlipidemia, and depression were also being treated.
His medications included regular insulin 3 times daily, insulin glargine, rosiglitazone, atorvastatin calcium, amlodipine besylate, quinapril hydrochloride, hydrochlorothiazide, and sertraline hydrochloride. He had been taking rosiglitazone for 3 years; the dosage had been increased from 2 to 8 mg/d in September 2003, . . . [Full Text of this Article]
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