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Arch Ophthalmol. 2005;123:1263-1264.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The gold standard for assessing the efficacy of a therapy is the controlled clinical trial. The Declaration of Helsinki mandates that clinical trials should only be performed with volunteers, and therefore the progress of medicine is absolutely dependent on the immense generosity of subjects willing to be part of a clinical trial. They do this in return for the greater good for society, yet this beneficence is not always returned. We know that many clinical trials are not reported, leading to difficulties in assessing the true efficacy of a therapy. Underreporting of clinical trials also can obscure the adverse effect profile of an intervention, as witnessed by the recent COX-2 inhibitor debacle.

In response, the International Committee of Medical Journal Editors (ICMJE), the World Health Organization, and even national political bodies have endorsed the concept of clinical trial registration. This proposal would require that details of a clinical trial be . . . [Full Text of this Article]

REQUIREMENTS FOR REGISTRATION


HOW IS REGISTRATION PERFORMED?

WHAT IF I DO NOT REGISTER MY CLINICAL TRIAL?

HOW IS CLINICAL TRIAL REGISTRATION JUSTIFIED?

AUTHOR INFORMATION
Leonard A. Levin, MD, PhD; Justin L. Gottlieb, MD; Roy W. Beck, MD, PhD; Daniel M. Albert, MD, MS
Archives of Ophthalmology

Thomas J. Liesegang, MD
American Journal of Ophthalmology

Creig S. Hoyt, MD; Andrew Dick, FRCS; Robert Bhisitkul, MD, PhD
British Journal of Ophthalmology

Andrew P. Schachat, MD
Ophthalmology

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