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Arch Ophthalmol. 2005;123:562-565.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Muir-Torre syndrome is a rare cancer predisposition syndrome characterized by unusual cutaneous tumors and internal malignancy.^1-2 The cutaneous tumors associated with Muir-Torre syndrome include mainly sebaceous gland neoplasms (sebaceous adenoma and sebaceous carcinoma), keratoacanthoma, and basal cell carcinoma.^1-3 Colorectal and genitourinary carcinoma are the common types of internal malignancies that occur in Muir-Torre syndrome.³ Although Muir-Torre syndrome is characterized by autosomal dominant inheritance, sporadic cases are known to occur. Significant variation can occur in the phenotypic manifestations of Muir-Torre syndrome, and in some cases Muir-Torre syndrome may resemble hereditary nonpolyposis colorectal carcinoma.^4-5 Recent investigations into the molecular genetics of Muir-Torre syndrome have revealed genomic replication errors, known as microsatellite instabilities, due to mutations in the mismatch repair genes, hMSH2 and hMLH1.⁶ In this report, we present the clinical and histologic features of a patient with Muir-Torre syndrome who had multiple facial lesions, some of which involved the eyelid, in . . . [Full Text of this Article]

Report of a Case


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AUTHOR INFORMATION
Arun D. Singh, MD, FRCS, FRCOphth; Hardeep Singh Mudhar, BSc, MBBChir, PhD, MRCPath; Ronnie Bhola, FRCOphth; Paul A. Rundle, FRCOphth; Ian G. Rennie, FRCS, FRCOphth