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Arch Ophthalmol. 2005;123:267-269.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Behçet disease (BD) is an inflammatory disorder of unknown cause with recurrent ocular, vascular, central nervous system, articular, mucocutaneous, and gastrointestinal manifestations. Most manifestations of BD are self-limiting, but repeated attacks of uveitis are a major cause of blindness.¹ Behçet disease is prevalent and is a major cause of morbidity in most Asian nations, countries along the ancient Silk Road, and the Mediterranean basin.¹

Biopsy specimens from active lesions of BD show large numbers of neutrophils in the absence of infection, and neutrophils from patients with BD show increased superoxide anion production, enhanced chemotaxis, and excessive release of granular enzymes, indicating neutrophil hyperactivity in BD.¹ Similarly, levels of circulating tissue necrosis factor , interleukin (IL) 1, and IL-8 are high, and it is believed that these cytokines are involved in neutrophil activation and the enhanced cellular interactions between neutrophils and endothelial cells as a consequences of up-regulated expression of . . . [Full Text of this Article]

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AUTHOR INFORMATION
Koh-Hei Sonoda, MD, PhD; Shoich Inaba, MD, PhD; Akiko Ariyama, MD; Yoh-Ich Kawano, MD, PhD; Abby Saniabadi, PhD; Tatsuro Ishibashi, MD, PhD