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Arch Ophthalmol. 2005;123:1745-1746.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Age-related macular degeneration (AMD) is the leading cause of legal blindness among people 65 years and older.¹ The cause of AMD is unclear, but oxidative stress may play a role because photoreceptors, which are high in readily oxidized polyunsaturated fatty acids, are exposed to high oxygen tensions and photo-oxidation. Antioxidant vitamins decrease the risk of vision loss in some patients with AMD, supporting the role of oxidative stress in AMD.² Iron can cause oxidative stress, and we have found that maculae from patients with AMD have higher iron levels in the retinal pigment epithelium (RPE) and Bruch’s membrane than do maculae from age-matched control subjects.³ Although elevated iron levels may be associated with AMD but not necessarily causal, recent evidence supports causality; we have found that retinas from iron-overloaded (ceruloplasmin/hephaestin–deficient) mice have some features of AMD and that a patient with retinal iron overload resulting from the rare hereditary disease . . . [Full Text of this Article]

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AUTHOR INFORMATION
Tzvete Dentchev, MD; Paul Hahn, PhD; Joshua L. Dunaief, MD, PhD

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