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Fluorescein Interference With Homocysteine Testing
Arch Ophthalmol. 2005;123:114-116.
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Measuring plasma homocysteine levels is increasingly common in the evaluation of patients with retinal vascular disease for a possible hypercoagulable state. Fluorescein administered in angiographic studies may interfere with blood tests using fluorescein-labeled reagents, as well as other methods, measuring near its 493.5-nm absorption maximum or 525-nm emission wavelengths or involving fluorescence quenching. To our knowledge, this is the first report of fluorescein interference with plasma homocysteine testing.
Report of a Case
A 37-year-old man was referred to the Lahey Clinic in Burlington, Mass, for decreased vision of 2 months’ duration in the right eye. The patient had a history of hypertension and Crohn disease for which he took multiple medications, including prednisone.
At initial examination, his best-corrected visual acuity was 20/80 OD and 20/25 OS. Results from dilated funduscopic examination, fluorescein angiography, and optical coherence tomography were consistent with findings of a central retinal vein occlusion in the right eye.
Workup for a . . . [Full Text of this Article]
AUTHOR INFORMATION
Nancy L. Flattem, MD;
Jeffrey L. Marx, MD;
John Gawoski, MD
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