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The Ocular Complications of Smallpox and Smallpox Immunization
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The public health threat of smallpox reintroduction requires rapid dissemination of treatment guidelines for smallpox and smallpox (vaccinia) vaccine complications. The timely publication of 2 articles1-2 in the ARCHIVES has introduced treatment options for ocular complications of smallpox and smallpox immunization.
Current guidelines for the treatment of vaccinia complications are based predominately on expert opinion because there are no controlled clinical studies of the treatment of ocular vaccinia in humans and only limited controlled clinical studies of the treatment of ocular vaccinia in animal models. Because there is a paucity of data regarding the efficacy of treatment options for vaccinia complications, the Centers for Disease Control and Prevention (CDC), in November 2002, convened a panel of infectious disease, ophthalmology, epidemiology, and smallpox eradication experts to review the literature and to offer consultation regarding guidance to clinicians for the treatment of ocular vaccinia. These recommendations have been published.3
In Semba's summary . . . [Full Text of this Article]
Janine A. Smith, MD;
Christine G. Casey, MD;
Bruce C. Tierney, MD
Correspondence: Dr Smith, National Eye Institute, National Institutes of Health, 10 Center Dr, MSC 1863, Bethesda, MD 20892-1863 (smithj@nei.nih.gov).
RELATED ARTICLE
The Ocular Complications of Smallpox and Smallpox Immunization—Reply
Richard D. Semba
Arch Ophthalmol. 2004;122(9):1407-1408.
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