Ocular Adnexal Lymphoma: Clinical Behavior of Distinct World Health Organization Classification Subtypes
Purpose: To evaluate the clinical behavior and treatment outcome of ocular adnexal lymphomas classified by the World Health Organization Classification, with emphasis on marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT).
Methods: The clinico-pathologic materials were reviewed in 98 consecutive patients treated for ocular adnexal lymphoma. Fourteen patients had prior lymphoma while 84 patients had primary disease (75% stage I, 6% stage III, 19% stage IV.) Radiation (photons/electrons) was administered to 102 eyes to 30.6 Gy median dose. Mean follow-up was 82 months.
Results: The most common subtypes among primary patients were MALT (57%) and follicular (18%) lymphoma. The 5-year actuarial local control rate in 102 irradiated eyes was 98%. Among the low-grade lymphomas, 5-year local control was correlated with radiation dose in the MALT lymphoma subgroup (N = 53): 81% for <30 Gy and 100% for
30Gy . . . [Full Text of this Article]