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Recurrent Anterior Uveitis in Patients With Vogt-Koyanagi-Harada Syndrome
Arch Ophthalmol. 2004;122:922-923.
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Vogt-Koyanagi-Harada (VKH) syndrome is a bilateral granulomatous panuveitis with central nervous system, auditory, and integumentary manifestations. Typically, ocular involvement is a panuveitis associated with choroidal lesions, exudative retinal detachments, and optic nerve inflammation. Treatment requires high-dose systemic corticosteroids, usually for a prolonged period, often with additional immunosuppressive agents.
Resolution without visually significant sequelae may occur, but complications including cataract, retinal pigment epithelial disturbances at the macula, and choroidal neovascular membrane formation are not infrequent.1 Vogt-Koyanagi-Harada syndrome has been reported to recur, typically as a recurrent anterior uveitis (AU) with or without recurrent posterior involvement. It has been suggested that such syndrome recurrence is directly related to the failure to prescribe adequate corticosteroid therapy in the initial phase of the syndrome.2
We report the manifestation, initial treatment, and clinical course of 3 patients with VKH syndrome who subsequently developed recurrent AU without further posterior segment involvement. Patients were identified from those . . . [Full Text of this Article] Report of Cases
Case 1 Case 2 Case 3
Comment
Simon Taylor, MA, MB, BChir, MRCOphth;
Susan Lightman, FRCP, PhD, FRCOphth, FMed, Sci
London, England
Corresponding author: Susan Lightman, FRCP, PhD, FRCOphth, FMed, Sci, Department of Clinical Ophthalmology, Institute of Ophthalmology, Moorfields Eye Hospital, City Road, London EC1V 2PD, England (e-mail: s.lightman@ucl.ac.uk).
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