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Transretinal Pigment Migration: An Optical Coherence Tomographic Study
Arch Ophthalmol. 2004;122:406-408.
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Cells of the retinal pigment epithelium (RPE) play an important role in the formation of epiretinal membranes after retinal detachment.1 The RPE cells may access the inner retinal surface through the retinal break that caused the detachment. Subsequent proliferation of these cells on the retinal surface then contributes to the formation of the epiretinal membranes, which typically consists of a variety of different cell types.
A second mechanism by which the RPE cells might access the inner retinal surface is by migration through the retina. The ability of proliferating RPE cells to migrate is well documented and can be altered by the cells' microenvironment.2-5 Proliferation of RPE cells occurs not infrequently after trauma and after retinal detachment repair.6-7 Experimental models of retinal detachment show that the RPE cell proliferation begins early in the course of the detachment and is confined to the region of the detachment.8-9 Translocation of RPE pigment . . . [Full Text of this Article] Report of Cases
Case 1 Case 2
Comment
David N. Zacks, MD, PhD;
Mark W. Johnson, MD
Ann Arbor, Mich
Corresponding author: David N. Zacks, MD, PhD, Retina Service, Kellogg Eye Center, University of Michigan Medical School, 1000 Wall St, Ann Arbor, MI 48105 (e-mail: davzacks@umich.edu).
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