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Leukocoria Caused by Intraocular Heterotopic Brain Tissue
Arch Ophthalmol. 2004;122:390-393.
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Leukocoria caused by diverse ocular conditions is distinguishable by history, characteristic clinical findings, and ancillary imaging. Atypical cases pose a diagnostic dilemma necessitating enucleation if retinoblastoma or malignancy cannot be excluded. We report a newborn with leukocoria in a microphthalmic eye containing an uncalcified subretinal mass. Teratoid medulloepithelioma was suspected. Instead, benign heterotopic brain tissue was found, which to our knowledge has only been reported once before,1 due to aberrant differentiation of the neurectoderm into cerebral gray matter instead of the retina.
Report of a Case
A 5-day-old, healthy baby girl with leukocoria of the microphthalmic right eye was seen in the Retinoblastoma Program at the Hospital for Sick Children, Toronto, Ontario. Perinatal and family histories were unremarkable. The left eye was normal, but the right eye appeared blind. Under general anesthesia, intraocular pressure and ocular movements were normal. The 8-mm-diameter right cornea was clear and the anterior chamber, deep. The iris was hypoplastic . . . [Full Text of this Article]
Comment
Sarit Patel, MD;
Daniel Albert, MD
Madison, Wis
Joanne Dondey, MD;
Helen S. L. Chan, MB, BS;
Elise Héon, MD;
Susan Blaser, MD;
Brenda L. Gallie, MD
Toronto, Ontario
Corresponding author and reprints: Brenda L. Gallie, MD, Department of Cancer Informatics, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, 610 University Ave, Toronto, Ontario, Canada M5G 2M9 (e-mail: gallie@attglobal.net).
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