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Cortical Blindness Due to Reversible Posterior Leukoencephalopathy Syndrome in a Patient With Thrombotic Thrombocytopenic Purpura and Preeclampsia
Arch Ophthalmol. 2004;122:1885-1887.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Neurological involvement in thrombotic thrombocytopenic purpura (TTP) is frequent. In one series, magnetic resonance imaging revealed brain lesions in 88% of the patients with TTP.1 The 2 most common cerebral lesions associated with TTP are edema and infarction.1-2 Cerebral edema predominantly affects the white matter, but when it affects gray matter in the territory of the posterior cerebral circulation, it may resemble the radiological findings of reversible posterior leukoencephalopathy syndrome (RPLS). We report a case of reversible cortical blindness caused by RPLS in a patient with TTP exacerbation and preeclampsia. To our knowledge, there have been only 10 previously reported cases of RPLS in the setting of TTP.1-2 We also discuss the role of diffusion-weighted imaging (DWI) in differentiating reversible from irreversible ischemic lesions.
Case Report
A 19-year-old, 28-week pregnant white woman came to the hospital with gross hematuria and decreased urine output. Her medical history was significant for recurrent episodes of . . . [Full Text of this Article] Comment
AUTHOR INFORMATION
Lenka Soltes, MD;
Ilona M. Schmalfuss, MD;
M. Tariq Bhatti, MD
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