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Optic Nerve Aplasia in an Infant With Congenital Hypopituitarism and Posterior Pituitary Ectopia
Arch Ophthalmol. 2004;122:125-126.
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Optic nerve aplasia is a rare developmental anomaly characterized by the congenital absence of the optic nerve, retinal blood vessels, and retinal ganglion cells.1-3 Optic nerve aplasia seems to fall within a malformation complex that is fundamentally distinct from optic nerve hypoplasia, as evidenced by its tendency to occur unilaterally and its frequent association with microphthalmos and other malformations that are confined to the involved eye.3-4 Unilateral optic nerve aplasia is generally associated with otherwise normal brain development, while bilateral optic nerve aplasia is usually accompanied by other central nervous system derangement.4 To our knowledge, optic nerve aplasia has not been associated with endocrinologic deficiency. This report describes congenital hypopituitarism and posterior pituitary ectopia in an infant with bilateral optic nerve aplasia.
Report of a Case
A male infant was born to nonconsanguineous parents at 38 weeks' gestation with a birth weight of 2750 g. There was no family history of microphthalmos or coloboma. . . . [Full Text of this Article]
Comment
Michael C. Brodsky, MD;
Sean-Paul A. Atreides, MD;
John L. Fowlkes, MD
Little Rock, Ark
Olof H. Sundin, PhD
Baltimore, Md
Corresponding author and reprints: Michael C. Brodsky, MD, Arkansas Children's Hospital, 800 Marshall, Little Rock, AR 72202 (e-mail: brodskymichael@exchange.uams.edu).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Bilateral aplasia of the optic nerve, chiasm, and tracts in an otherwise healthy infant.
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Br. J. Ophthalmol. 2006;90:513-514.
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