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Arch Ophthalmol. 2003;121:1201-1203.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In 1999, Morales et al¹ reported that 1.0% apraclonidine hydrochloride (Iopidine; Alcon, Ft Worth, Tex) could be used to diagnose Horner syndrome. Apraclonidine caused reversal of anisocoria (the miotic pupil with Horner syndrome became larger than the normal pupil) in all patients in their study. Apraclonidine is primarily an ₂-receptor agonist, but it does have some weak ₁ affinity, as evidenced by conjunctival blanching. The authors postulated that the reversal of anisocoria was due to denervation hypersensitivity of ₁-receptors in the pupil dilator muscle. The purpose of our study is to determine whether 0.5% apraclonidine, which is less expensive and more readily available than the 1.0% formulation, might also be used to diagnose Horner syndrome in the same lighting conditions.

Report of Cases

Patients with known or newly diagnosed Horner syndrome in 2 of our practices (those of R.A. and K.A.F.) were invited to participate, and institutional review board approval was obtained. Cases were . . . [Full Text of this Article]

Comment
Sandra M. Brown, MD
Lubbock, Tex

Rachid Aouchiche, MD
Ft Myers, Fla

Kenn A. Freedman, MD
Lubbock

Corresponding author: Sandra M. Brown, MD, 3601 Fourth St, Stop 7217, Lubbock, TX 79430 (e-mail: sandra.brown@ttuhsc.edu).

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