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Arch Ophthalmol. 2003;121:909-911.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Proton magnetic resonance spectroscopy (¹H-MRS) is an effective and useful technique for the metabolic analysis of tissues in vivo because it noninvasively identifies and quantifies tissue metabolites such as N-acetylaspartate, lactate, and choline.¹ This technique is frequently used to assess the chemical composition of normal and pathologic brain tissue to investigate infarction, neoplasm, and mitochondrial disease.² Similar application of ¹H-MRS to ocular disease may prove beneficial for the noninvasive analysis of intraocular metabolism. Tissues of particular metabolic interest, such as the optic nerve and retina, are not amenable to direct study with ¹H-MRS because of volume constraints and the high likelihood of contamination of the spectra by surrounding tissues. However, the relatively large size of the vitreous body should allow spectroscopic assessment of ocular metabolism. Lactate was the dominant metabolite detected in a study using ¹H-MRS with a high-field (4.7-T) magnetic resonance imaging (MRI) scanner to determine the . . . [Full Text of this Article]

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Corresponding author and reprints: Nancy J. Newman, MD, Neuro-ophthalmology Unit, Emory Eye Center, 1365-B Clifton Rd NE, Atlanta, GA 30322 (e-mail: ophtnjn@emory.edu).

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