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Endothelial Proliferation in Diabetic Retinal Microaneurysms
Edith Aguilar, MD;
Martin Friedlander, MD, PhD;
Ray F. Gariano, MD, PhD
La Jolla, Calif
Arch Ophthalmol. 2003;121:740-741.
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MECHANISMS OF microaneurysm formation in nonproliferativediabetic retinopathy include local structural weakness in the vessel wall with subsequent dilatation and focal vascular endothelial cell proliferation.1Either or both mechanisms maycontribute to aneurysm formationbecause some aneurysms are hypercellular, whereas others are thin-walled or hypocellular.1 We addressed these possibilities using histochemical markers of endothelial cells and cellular proliferation in human diabetic retinas.
Eyes were obtained within 12 hours of death from 5 patients with diabetes mellitus. The eyes were fixed in 4% paraformaldehyde, the corneas were removed, and the retinas were examined using a dissection microscope for pathological evidence of diabetic retinopathy. Retinas were removed from the eyecup and processed for fluorescence immunohistochemical analysis, as was previously described.2 Vascular endothelium was visualized using fluorescein isothiocyanate–conjugated Ulex europaeus lectin or antibodies to laminin (Sigma, St Louis, Mo). Proliferating cells were designated by . . . [Full Text of this Article] COMMENT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy
Gubitosi-Klug et al.
Diabetes 2008;57:1387-1393.
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