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Ultrasound Biomicroscopy in Management of Malignant Iris Melanoma
Arch Ophthalmol. 2003;121:725-727.
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High-frequency ultrasound biomicroscopy (UBM) provides high-resolution cross-sectional images of anterior segment structures. Few published reports have correlated abnormal UBM images with histopathologic findings. A recent report by Marigo et al1 compared ultrasound images of iris and ciliary body melanomas with their histopathologic features. They found that UBM accurately defined the tumor shape andthe extent of local invasion. There is histopathologic evidence that iris melanomas can spread through unguarded (Scheie procedure2 and iridencleisis3) and guarded (trabeculectomy4) glaucoma procedures. We show that UBM can accurately determine the depth of tissue penetration by an iris melanoma into a trabeculectomy site by correlating the clinical images with the histopathologic features after enucleation.
Report of a Case
In January 1995, a 59-year-old white woman was evaluated for rising intraocular pressure in the left eye. The patient had been prescribed timolol maleate, pilocarpine, apraclonidine hydrochloride, andacetazolamide by the referring ophthalmologist. She had a history of a pigmented iris . . . [Full Text of this Article]
Pathologic Description
Comment
Corresponding author and reprints: Dennis M. Robertson, MD, Department of Ophthalmology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (e-mail: robertson.dennis@mayo.edu).
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