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Improvement After Verteporfin Therapy
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In the Treatment of Age-Related Macular Degeneration With Photodynamic Therapy (TAP) Investigation,1-2 whereas some patients (22%) had no change (<5-letter increase or decrease) in visual acuity from baseline to the month 12 examination, some patients (10%) had an improvement in visual acuity of at least 5 letters but less than 15 letters, equivalent to at least 1 line but fewer than 3 lines of visual acuity, and a few patients (6%) had improvement of at least 15 letters, equivalent to at least 3 lines of visual acuity. Although patients with improvement represented only a small proportion of the total study population, analysis of these cases may help to identify ways of improving verteporfin therapy in the future and to determine whether there are correlations between vision improvement and fluorescein angiographic outcomes. Data from the TAP Investigation, using an intent-to-treat analysis with the last observation carried forward for missing values, showed . . . [Full Text of this Article]
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