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Unusual Superficial Variant of Granular Corneal Dystrophy With Amyloid Deposition
Arch Ophthalmol. 2003;121:269-271.
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Superficial granular corneal dystrophy (SGCD) is a variant of GCD that is restricted to involvement of the Bowman layer and the superficial corneal stroma.1-2 Superficial and classic GCD result from mutations in the human transforming growth factor  –induced gene (BIGH3) on human chromosome 5 (5q31).3-4 We report an unusual case of a patient with SGCD in which the typical deposits of GCD were associated with amyloid and in which the 2 commonly affected exons (4 and 12) of the BIGH3 gene were not mutated.
Report of a Case
A 40-year-old woman from northern India sought care because of gradual decreasing vision in both eyes during the preceding 25 years. On examination, her visual acuity was 1/60 OU. Slitlamp biomicroscopy revealed bilateral dense opacities in the superficial portion of the corneal stroma, with clear areas between the deposits (Figure 1A and B). The deposits were most marked centrally, with a peripheral . . . [Full Text of this Article]
Comment
Corresponding author: Seymour Brownstein, MD, University of Ottawa Eye Institute, 501 Smyth Rd, Room 3818, Ottawa, Ontario, Canada K1H 8L6 (e-mail: sbrownstein@ohri.ca).
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