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Arch Ophthalmol. 2003;121:1637-1640.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Bilateral diffuse uveal melanocytic proliferation (BDUMP) syndrome is a rare paraneoplastic disorder characterized by bilateral diffuse infiltration of the uvea by melanocytic tumors in the presence of an associated systemic malignant neoplasm.¹ The uveal involvement is de novo and occurs in the absence of melanocytic metastasis. Since the description by Machemer,² about 22 cases have been published.³ The mean age at BDUMP syndrome diagnosis is 63 years (range, 34-89 years), with a preponderance in women (13:7). In half of the cases, the ocular symptoms manifest before the diagnosis of an underlying malignancy. The most common malignancies associated with BDUMP syndrome are poorly differentiated carcinomas arising from the ovaries and uterus in women and lung carcinomas in men.³ In a detailed study of 4 cases, Gass et al⁴ outlined the cardinal ocular signs, which included rapidly progressive cataracts in addition to the fundus changes secondary to uveal melanocytic proliferation.

In addition, . . . [Full Text of this Article]

Report of a Case


Comment
Arun D. Singh, MD, FRCS, FRCOphth; Paul A. Rundle, FRCOphth; David N. Slater, FRCPath; Ian G. Rennie, FRCS, FRCOphth; Andrew Parsons, FRCPath; Andrew J. G. McDonagh, FRCP
Sheffield, England

Corresponding author: Arun D. Singh, MD, FRCS, FRCOphth, Department of Ophthalmology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, England (e-mail: arunsingh@eyetumors.com).